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1.      Kinoshita, T., Imamura, R., Kushiyama, H., and Suda, T.: NLRP3 mediates NF-ƒČB activation and cytokine induction in microbially induced and sterile inflammation. PLoS One. 2015, 10(3):e0119179

 

2.      Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S., and Suda, T. Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages. Int. Immunol. 2013, 25(6):363-372.

 

3.      Harashima, N., Inao, T., Imamura, R., Okano, S., Suda, T., and Harada, M.: Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells. Cancer Immunol. Immunother. 2012, 61(5):667-676

 

4.      Motani, K., Kushiyama, H., Imamura, R., Kinoshita, T., Nishiuchi, T., and Suda, T.: Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity. J. Biol. Chem. 2011, 286(39):33963-33972

 

5.      Motani, K., Kawase, K., Imamura, R., Kinoshita, T., Kushiyama, H., and Suda, T.: Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication. Cancer Sci. 2010. 101(8):1822-1827

 

6.      Imamura, R., Wang, Y., Kinoshita, T., Suzuki, M., Noda, T., Sagara, J., Taniguchi, S., Okamoto, H., and Suda, T.: Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J. Immunol. 2010. 184(10):5874-5884.

 

7.      Hasegawa, M., Imamura, R., Motani, K., Nishiuchi, T., Matsumoto, N., Kinoshita, T., and Suda, T.: Mechanism and repertoire of ASC-mediated gene expression. J. Immunol. 2009, 182(12):7655-7662

 

8.      Ohno, S.,@Kinoshita, T., Ohno, Y., Minamoto, T., Suzuki N., Inoue M., and Suda, T.: Expression of NLRP7 (PYPAF3, NALP7)Protein in Endometrial Cancer Tissues. Anticancer Res. 2008. 28(4C):2493-2497.

 

9.   Matsumoto, N., Imamura, R., Suda, T.: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production. FEBS J. 2007/5, 274(9):2376-2384

 

10.   Umemura, M., Yahagi, A., Hamada, S., Begum, M. D., Watanabe, H., Kawakami, K., Suda, T., Sudo, K., Nakae, S., Iwakura, Y., and Matsuzaki, G.: IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis BCG infection, J. Immunol., 2007/3, 178(6):3786-3796.

 

11.   Fujisawa, A., Kambe, N., Saito, M., Nishikomori, R., Tanizaki, H., Kanazawa, N., Adachi, S., Heike, T., Sagara, J., Suda, T., Nakahata, T., Miyachi, Y.: Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells, Blood, 2007/4, 109(7):2903-2911.

 

12.   Kinoshita, T., Kondoh, C., Hasegawa, M., Imamura, R., and Suda, T.: Fas-associated Factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1, Int. Immunol., 2006, 18:1701-1706.

 

13.   El Kasmi, K.C., Holst J, Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., Smith, A.M., Rutschman, R., Kaushal, D., Shen, Y., Suda, T., Donnelly, R.P., Myers, M.G. Jr., Alexander, W., Vignali, D.A., Watowich, S.S., Ernst, M., Hilton, D.J., Murray, P.J.: General nature of the STAT3-activated anti-inflammatory response. J. Immunol., 2006, 177:7880-7888.

 

14.   Hasegawa, M., Kawase, K., Inohara, N., Imamura, R., Yeh, W-C.,Kinoshita, T., and Suda, T.: Mechanism of ASC-mediatedapoptosis: Bid-dependent apoptosis in type II cells, Oncogene, 2006, In press.

 

15.   Kidoya, H., Umemura, U., Kawabe, T.,Matsuzaki, G., Yahagi, A., Imamura, R., and Suda, T. (2005) Fas ligand inducescell-autonomous IL-23 production in dendritic cells, a mechanism for Fasligand-induced IL-17 production. J. Immunol.175:8024-31. [PubMed]

 

16.   Kinoshita,T., Wang, Y., Hasegawa, M., Imamura, R., and Suda, T. (2005) PYPAF3, aPYRIN-containing APAF-1-like protein, is a feedback regulator ofcaspase-1-dependent interleukin-1b secretion. J. Biol. Chem. 280:21720-5[PubMed]

 

17.   Hasegawa M,Imamura R, Kinoshita T, Matsumoto N, Masumoto J, Inohara N, and Suda T. (2005)ASC-mediated NF-kB activation leading to interleukin-8 productionrequires caspase-8 and is inhibited by CLARP. J. Biol. Chem. 280: 15122-30. [PubMed]

 

18.   Imamura, R.,Konaka, K., Matsumoto, N., Hasegawa, M., Fukui, M., Mukaida, N., Kinoshita, T., and Suda, T. (2004) Fas ligandinduces cell-autonomous NF-kB activation and IL-8 production by a mechanismdistinct from that of TNF-a. J. Biol. Chem.279:46415-23. [PubMed]

 

19.   Umemura, M.,Kawabe, T., Shudo, K., Kidoya, H., Fukui, M., Asano, M., Iwakura, Y.,Matsuzaki, G., Imamura, R., and Suda, T. (2004) Involvement of IL-17 in Fasligand-induced inflammation. Int. Immunol. 16:1099-108.[PubMed]

 

20.   Wang, Y.,Hasegawa, M., Imamura, R., Kinoshita, T., Kondo, C., Konaka, K., Suda, T.(2004) PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC andcaspase-1. Int. Immunol. 16:777-86. [PubMed]

 

21.   Nakamoto Y, SudaT, Momoi T, and Kaneko S. (2004) Different procarcinogenic potentials oflymphocyte subsets in a transgenic mouse model of chronic hepatitis B. CancerRes. 64:3326-3333 [PubMed]

 

22.   Fukui, M.,Imamura, R., Umemura, M., Kawabe, T., Suda, T. (2003) Pathogen-associatedmolecular patterns sensitize macrophages to Fas ligand-induced apoptosis andIL-1beta release. J. Immunol.. 171:1868-74. [PubMed]

 

23.   Tachiiri,A., Imamura, R., Wang, Y., Fukui, M., Umemura, M., and Suda, T. (2003) Genomicstructure and inducible expression of the IL-22 receptor a chain in mice. Gene. Immun., 4:153-159 [PubMed]

 

24.   Nakamoto, Y.Kaneko, S., Fan, H., Momoi, T., Tsutsui, H., Nakanishi, K., Kobayashi, K., andSuda, T. (2002) Prevention of Hepatocellular Carcinoma Development Associatedwith Chronic Hepatitis by Anti-Fas Ligand Antibody Therapy. J. Exp. Med.,196:1105-1111 [PubMed]

 

25.   Fukuyama H,Adachi M, Suematsu S, Miwa K, Suda T, Yoshida N, Nagata S. (2002) Requirementof Fas expression in B cells for tolerance induction. Eur. J. Immunol.32:223-30. [PubMed]

 

26.   Shudo, K.,Kinoshita, K., Imamura, R., Fan, H., Hasumoto, K., Tanaka, M., Nagata, S., andSuda, T. (2001) The membrane-bound but not the soluble form of human Fas ligandis responsible for its inflammatory activity. Eur. J.Immunol., 31:2504-2511 [PubMed]

 

27.   Miwa, K,Hashimoto, H., Yatomi, T., Nakamura, N., Nagata, S., and Suda, T. (1999)Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus- hostdisease. Int Immunol 11:925-931 [PubMed]

 

28.   Saito, I.,Haruta, K., Shimuta, M., Inoue, H. Sakurai, H., Yamada, K., Ishimaru, N.,Higashiyama, H., Sumida, T., Ishida, H., Suda, T., Noda, T., Hayashi, Y., andTsubota, K. (1999) Fas ligand-mediated exocrinopathy resembling Sjogren'ssyndrome in mice transgenic for IL-10. J Immunol 162:2488-2494 [PubMed]

 

29.   Kuwano, K.,Hagimoto, N., Kawasaki, M., Yatomi, T., Nakamura, N., Nagata, S., Suda, T.,Kunitake, R., Maeyama, T., Miyazaki, H., and Hara, N. (1999) Essential roles of the Fas-Fas ligand pathway in thedevelopment of pulmonary fibrosis. J Clin Invest 104:13-19 [PubMed]

 

30.   Miwa, K.,Asano, M., Horai, R., Iwakura, Y., Nagata, S., and Suda. T. (1998) Caspase1-independent IL-1beta release and inflammation induced by the apoptosis inducerFas ligand. Nat. Med. 4:1287-92. [PubMed]

 

31.   Fukuyama,H., Adachi, M., Suematsu, S., Miwa, K., Suda, T., Yoshida, N., and Nagata, S.(1998) Transgenic expression of Fas in T cells blocks lymphoproliferation butnot autoimmune disease in MRL-lpr mice. J Immunol 160:3805-3811. [PubMed]

 

32.   Hashimoto,H., Tanaka, M., Suda, T., Tomita, T., Hayashida, K., Takeuchi, E., Kaneko, M.,Takano, H., Nagata, S., and Ochi, T. (1998) Soluble Fas ligand in the joints ofpatients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum41:657-662. [PubMed]

 

33.   Suda, T., Hashimoto,H., Tanaka, M., Ochi, T., and Nagata, S. (1997) Membrane Fas ligand kills humanperipheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J.Exp. Med. 186:2045-2050. [PubMed]

 

34.   Hueber, A.O., Zornig, M., Lyon, D., Suda, T., Nagata, S., and Evan, G. I. (1997)Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis.Science 278:1305-1309. [PubMed]

 

35.   Tsutsui, T.,Mu, J., Ogawa, M., Yu, W., Suda, T., Nagata, S., Saji, F., Murata, Y., Fujiwara, H., Hamaoka, T.(1997) Administration of IL-12 induces a CD3+CD4-CD8-B220+ lymphoidpopulation capable of eliciting cytolysis against Fas-positive tumorcells. J. Immunol. 159:2599-2605. [PubMed]

 

36.   Kondo, T., Suda,T., Fukuyama, H., Adachi, M., and Nagata, S. (1997) Essential roles of the Fasligand in the development of hepatitis. Nature Med. 3:409-413. [PubMed]

 

37.   Tanaka, M.,Suda, T., Yatomi, T., Nakamura, N., and Nagata, S. (1997). Lethal effect ofrecombinant human Fas ligand in mice pretreated with propionibacterium acnes.J. Immunol. 158:2303-2309 [PubMed]

 

38.   Adachi, M.,Suemura, S., Suda, T., Watanabe, D., Fukuyama, H., Ogasawara, J., Tanaka, T.,Yoshida, N., and Nagata, S. (1996). Enhanced and accelerated lymphoproliferationin Fas-null mice. Proc. Natl. Acad. Sci. 96:2131-2136. [PubMed]

 

39.   Tanaka, M., Suda,T., Haze, K., Nakamura, N., Sato, K., Kimura, F., Motoyoshi, K., Mizuki, M.,Tagawa, S., Ohga, S., Hatake, K., Drummond, A. H. and Nagata, S. (1996). Fasligand in human serum. Nature Med. 2:317- 322. [PubMed]

 

40.   Suda, T.,Tanaka, M., Miwa, K., and Nagata, S. (1996). Apoptosis of mouse naive T cellsinduced by recombinant soluble Fas ligand and activation-induced resistance toFas ligand. J. Immunol. 157:3918-3924. [PubMed]

 

41.   Estaquier, J., Tanaka, M., Suda, T., Nagata, S.,Golstein, P., and Ameisen, J.C. (1996). Fas-mediated apoptosis of CD4+ and CD8+T cells from human immunodeficiency virus-infected persons: differential invitro preventive effect of cytokines and protease antagonists. Blood.87:4959-4966. [PubMed]

 

42.   Takahashi,T., Tanaka, M., Ogasawara, J., Suda, T., Murakami, H., Nagata, S. (1996).Swapping between Fas and granulocyte colony-stimulating factor receptor. J.Biol. Chem. 271:17555-17560. [PubMed]

 

43.   Yamashita,Y., Miyake, K., Miura, Y., Kaneko, Y., Yagita, H., Suda, T., Nagata, S.,Nomura, J., Sakaguchi, N., Kimoto, M. (1996). Activation Mediated by RP105 butnot CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: a rolefor Fc receptor co-ligation. J. Exp Med. 184:113-120. [PubMed]

 

44.   Nishio, A.,Katakai, T., Oshima, C., Kasakura, S., Sakai, M., Yonehara, S., Suda, T.,Nagata, S., and Masuda, T. (1996). A possible involvement of Fas-Fas ligandsignaling in the pathogenesis of murine autoimmune gastritis. Gastroenterology111:959-967.

 

45.   Ogasawara,J., Suda, T., and Nagata, S. (1995). Selective apoptosis of CD4+CD8+ thymocytesby the anti-Fas antibody. J. Exp. Med. 181:485-491. [PubMed]

 

46.   Tanaka, M.,Suda, T., Takahashi, T., and Nagata, S. (1995). Expression of the functionalsoluble form of human Fas ligand in activated lymphocytes. EMBO J.14:1129-1135. [PubMed]

 

47.   Watanabe,D., Suda, T. and Nagata, S. (1995). Expression of Fas in B cells of the mousegerminal center and Fas-dependent killing of activated B cells. Int. Immunol.7:1949-1956. [PubMed]

 

48.   Suda, T.,Okazaki, T., Naito, Y., Yokota, T., Arai, N., Ozaki, S., Nakao, K., and Nagata,S. (1995). Expression of the Fas ligand in cells of T-cell-lineage. J. Immunol.154:3806-3813. [PubMed]

 

49.   Watanabe,D., Suda, T., Hashimoto, H., and Nagata, S. (1995). Constitutive activation ofthe Fas ligand gene in mouse lymphoproliferative disorders. EMBO J. 14:12-18. [PubMed]

 

50.   Suda, T.,and Nagata, S. (1994). Purification and characterization of the Fas-ligand thatinduces apoptosis. J. Exp. Med. 179:873-878. [PubMed]

 

51.   Takahashi,T., Tanaka, M., Brannan, C.I., Jenkins, N.A., Copeland, N.G., Suda, T., andNagata, S. (1994). Generalized lymphoproliferative disease in mice, caused by apoint mutation in the Fas ligand. Cell. 76:969-976. [PubMed]

 

52.   Takahashi, T.,Tanaka, M., Inazawa, J., Abe, T., Suda, T., and Nagata, S. (1994). Human Fasligand; gene structure, chromosomal location and species specificity. Int.Immunol. 6:1567-1574. [PubMed]

 

53.   Suda, T.,Takahashi, T., Golstein, P., and Nagata, S. (1993). Molecular cloning andexpression of the Fas ligand: a novel member of the tumor necrosis factorfamily. Cell. 75:1169-1178. [PubMed]

 

54.   Ogasawara,J., Watanabe, F.R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh,N., Suda, T., and Nagata, S. (1993). Lethal effect of the anti-Fas antibody inmice. Nature. 364:806-809. [PubMed]

 

55.   Suda, T. andZlotnik, A. (1993). Origin, differentiation, and repertoire selection ofCD3+CD4-CD8- thymocytes bearing either ab or gd T cell receptors. J. Immunol. 150:447-455. [PubMed]

 

56.   Godfrey,D.I., Kennedy, J., Suda, T., and Zlotnik, A. (1993). A developmental pathwayinvolving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J.Immunol. 150:4244-4252. [PubMed]

 

57.   Godfrey,D.I., Zlotnik, A., and Suda, T. (1992). Phenotypic and functionalcharacterization of c-kit expression during intrathymic T cell development. J.Immunol. 149:2281-2285. [PubMed]

 

58.   Suda, T. andZlotnik, A. (1992). In vitro induction of CD8 expression on thymic pre-T cells.II. Characterization of CD3-CD4-CD8a+ cells generated in vitro by culturingCD25+CD3-CD4-CD8- thymocytes with T cell growth factor-b and tumor necrosisfactor-a. J. Immunol. 149:71-76. [PubMed]

 

59.   Shimizu, J.,Suda, T., Katagiri, T., Fujiwara, H., and Hamaoka, T. (1992). Tumor-specific Tcell lines: capacity to proliferate and produce interleukin 2 in response tovarious forms of tumor antigens. Jpn. J. Cancer Res. 83:184-193. [PubMed]

 

60.   Zlotnik, A.,Godfrey, D.I., Fischer, M., and Suda, T. (1992). Cytokine production by matureand immature CD4-CD8- T cells. ab-T cell receptor+ CD4-CD8- T cells produceIL-4. J. Immunol. 149:1211-1215. [PubMed]

 

61.   Suda, T. andZlotnik, A. (1992). In vitro induction of CD8 expression on thymic pre-T cells.I. Transforming growth factor-b and tumor necrosis factor-a induce CD8 expression on CD8- thymicsubsets including the CD25+CD3-CD4-CD8- pre-T cell subset. J. Immunol.148:1737-1745. [PubMed]

 

62.   Suda, T. andZlotnik, A. (1991). IL-7 maintains the T cell precursor potential ofCD3-CD4-CD8- thymocytes. J. Immunol. 146:3068-3073. [PubMed]

 

63.   Fischer, M.,MacNeil, I., Suda, T., Cupp, J.E., Shortman, K., and Zlotnik, A. (1991).Cytokine production by mature and immature thymocytes. J. Immunol.146:3452-3456. [PubMed]

 

64.   Suda, T.,Murray, R., Guidos, C., and Zlotnik, A. (1990). Growth-promoting activity ofIL-1a, IL-6, andtumor necrosis factor-a in combination with IL-2, IL-4, or IL-7 on murinethymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3-double-negative thymocytes. J. Immunol. 144:3039-3045. [PubMed]

 

65.   MacNeil,I.A., Suda, T., Moore, K.W., Mosmann, T.R., and Zlotnik, A. (1990). IL-10, anovel growth cofactor for mature and immature T cells. J. Immunol.145:4167-4173. [PubMed]

 

66.   Suda, T.,Murray, R., Fischer, M., Yokota, T., and Zlotnik, A. (1990). Tumor necrosisfactor-a and P40induce day 15 murine fetal thymocyte proliferation in combination with IL-2. J.Immunol. 144:1783-1787. [PubMed]

 

67.   Suda, T.,O'Garra, A., MacNeil, I., Fischer, M., Bond, M.W., and Zlotnik, A. (1990).Identification of a novel thymocyte growth-promoting factor derived from B celllymphomas. Cell. Immunol. 129:228-240. [PubMed]

 

68.   Murray, R.,Suda, T., Wrighton, N., Lee, F., and Zlotnik, A. (1989). IL-7 is a growth andmaintenance factor for mature and immature thymocyte subsets. Int. Immunol.1:526-531. [PubMed]

 

69.   Shimizu, J.,Suda, T., Yoshioka, T., Kosugi, A., Fujiwara, H., and Hamaoka, T. (1989).Induction of tumor-specific in vivo protective immunity by immunization with tumorantigen-pulsed antigen-presenting cells. J. Immunol. 142:1053-1059.[PubMed]

 

70.   Suda, T.,Hodgkin, P., Lee, F., and Zlotnik, A. (1989). Biological activity ofrecombinant murine interleukin-6 in interleukin-1 T cell assays. J. Immunol.Methods. 120:173-178.

 

71.   Suda, T.,Shimizu, J., Muramatsu, M., Kimura, K., Yoshida, T.O., Fukami, Y., Fujiwara,H., and Hamaoka, T. (1989). The tumor rejection antigen separated from Roussarcoma virus-induced murine fibrosarcoma exhibits a molecular weight ofapproximately 60 kD but differs from functional pp60src. Jpn. J. Cancer Res.80:879-886.

 

72.   Sato, S.,Qian, J.H., Kokudo, S., Ikegami, R., Suda, T., Hamaoka, T., and Fujiwara, H.(1988). Studies on the induction of tolerance to alloantigens. III. Inductionof antibodies directed against alloantigen-specific delayed-typehypersensitivity T cells by a single injection of allogeneic lymphocytes viaportal venous route. J. Immunol. 140:717-722.

 

73.   Suda, T.,Sano, S., Hori, S., Azuma, T., Tateishi, N., Hamaoka, T., and Fujiwara, H.(1988). Prevention of suppression of alloreactive capacity followingintravenous injection of neuraminidase-treated allogeneic cells by co-injectionof agents competing for asialoglycoprotein receptor. Reg. Immunol. 1:24-31.

 

74.   Suda, T.,Shimizu, J., Mizushima, Y., Fujiwara, H., and Hamaoka, T. (1988). Separation ofthe tumor rejection antigen of Rous sarcoma virus-induced murine fibrosarcoma.Jpn. J. Cancer Res. 79:365-374.

 

75.   Sano, S.,Suda, T., Qian, J.H., Sato, S., Ikegami, R., Hamaoka, T., and Fujiwara, H.(1987). Abrogation of the capacity of delayed-type hypersensitivity responses toalloantigens by intravenous injection of neuraminidase-treated allogeneiccells. J. Immunol. 139:3652-3659.

 

76.   Kosugi, A.,Yoshioka, T., Suda, T., Sano, H., Takahama, Y., Fujiwara, H., and Hamaoka, T.(1987). The activation of L3T4+ helper T cells assisting the generation ofanti-tumor Lyt-2+ cytotoxic T lymphocytes: requirement of Ia-positiveantigen-presenting cells for processing and presentation of tumor antigens. J.Leukoc. Biol. 42:632-641.

 

77.   Suda, T.,Fujiwara, H., Mizushima, Y., Shearer, G.M., and Hamaoka, T. (1986). Role ofTNP-reactive helper T cells in augmenting anti-tumor immune response: Enhancedinduction of tumor-specific Lyt-1+2- T cell-mediated delayed-typehypersensitivity from spleen cells of tumor-bearing mice by TNP-helpers. J. Natl.Cancer Inst. 77:1267-1272.

 

78.   Ohta, A.,Suda. T., Kiyono, K., and Shibuya, I. (1986). Over production of proteinsencoded by l replicon-integrated plasmid: Effect of partial inactivation of cIrepressor. Plasmid. 15:159-162.

 

79.   Fujiwara,H., Moriyama, Y., Suda, T., Tsuchida, T., Shearer, G.M., and Hamaoka, T.(1984). Enhanced TNP-reactive helper T cell activity and its utilization in theinduction of amplified tumor immunity which results in tumor regression. J.Immunol. 132:1571-1577.

 

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